Ley/H: an endothelial-selective, cytokine-inducible, angiogenic mediator.

Le/H: An Endothelial-Selective, Cytokine-Inducible, Angiogenic Mediator

Response of Endothelial Progenitor Cells and Expression of Angiogenic Cytokine Genes in Preconditioning with Resistance Training in Elderly Men

Introduction: Impairment in the endothelial function starts with aging; however, it can be reduced or prevented by regular exercise. This study aimed to investigate the response and compatibility of endothelial progenitor cells and to evaluate the gene expression of hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) after eight weeks of resistance training in the e...

Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis.

AIMS Neuregulins (NRG) are growth factors that are synthesized by endothelial cells (ECs) and bind to erbB receptors. We have shown previously that NRG is proangiogenic in vitro, and that NRG/erbB signalling is important for autocrine endothelial angiogenic signalling in vitro. However, the role of NRG in the angiogenic response to ischaemia is unknown. We hypothesized that endothelial NRG is r...

An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality.

BACKGROUND Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissue perfusion), but also of key aspects of local and systemic inflammatory responses. Previous efforts to develop inhibitors of NOS to protect against NO-mediated tissue damage in...

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia

Purpose Disappointing results from clinical studies assessing the efficacy of therapies targeting vascular endothelial growth factor (VEGF) for the treatment of pterygia suggest that other angiogenic mediators may also play a role in its development. We therefore explore the relative contribution of VEGF, hypoxia-inducible factor (HIF)-1α (the transcription factor that regulates VEGF expression...